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Publications
Some of the numerous publications of Micronics' microfluidic platform technology include:
C. Lancaster, M. Kokoris, M. Nabavi, J. Clemmens, P. Maloney, J. Capodanno, J. Gerdes,
C. F. Battrell, “Rare cancer cell analyzer for whole blood applications: Microcytometer
cell counting and sorting subcircuits”, METHODS 37 (2005) 120-127
M. Kokoris, M. Nabavi, C. Lancaster, J. Clemmens, P. Maloney, J. Capodanno, J. Gerdes,
C. F. Battrell, “Rare cancer cell analyzer for whole blood applications: Automated nucleic
acid purification in a microfluidic disposable card”, METHODS 37 (2005), 114-119
B. H. Weigl, C. J. Morris, N. Kesler, C. F. Battrell, R. L. Bardell,
"Standard and high-throughput microfluidic disposables based on
laminar fluid diffusion interfaces" SPIE BIOS 2002, San Jose, January
2002.
B. H. Weigl and K. Hedine, "Lab-on-a-chip-based separation and detection
technology for life science applications", American Biotechnology
Laboratory, Jan. 2002, Vol. 20:1 pp28-30.
B.H. Weigl, R. L. Bardell, T. H. Schulte, C. F. Battrell, J. Hayenga,
"Design and Rapid Prototyping of Thin-Film Laminate-Based Microfluidic
Devices" Biomedical Microdevices 2001, Vol. 3:4 pp 267-274, 2001,
Kluwer Academic Publishers.
B. H. Weigl, C. J. Morris, N. Kesler, P. Saltsman, R. L. Bardell, "Well-Plate
Formats and Microfluidics - Applications of Laminar Fluid Diffusion Interfaces
to HTP Screening", uTAS 2001. 383-384, D. J. Harrison and A. van
den Berg, eds. Kluwer Academic Publishers, Dordrecht, (2001).
A. Hatch, A. Kamholz, K. Hawkins, M. Munson, E. Shilling, B. H. Weigl,
P. Yager, "A rapid diffusion immunoassay in a T-Sensor", Nature
Biotechnology, Vol. 19, pp461-465, 2001.
B. H. Weigl, R. L. Bardell, N. Kesler, C. J. Morris, "Lab-on-a-chip
sample preparation using Laminar Fluid Diffusion Interfaces - CFD Model
Results and Fluidic Verification Experiments" Fresenius Journal
of Analytical Chemistry 2001, 371:97-105.
R. L. Bardell, B. H. Weigl, N. Kesler, T.H. Schulte, J. Hayenga, C.F.
Battrell, "Microfluidic Disposables for Cellular and Chemical Detection
- CFD Model Results and Fluidic Verification Experiments" , SPIE
BIOS 2001, San Jose, January 2001.
B. H. Weigl, R. L. Bardell, N. Kesler, C. J. Morris, "Lab-on-a-chip
sample preparation using Laminar Fluid Diffusion Interfaces - Computational
Fluid Dynamics Model Results and Fluidic Verification Experiments",
SPIE BIOS 2001, 4265-02, 2001.
Darling, Yager, Weigl, Kriebel, Mayes "Integration Of Microelectrodes
with Etched Microchannels for In-stream Electrochemical Analysis" .
B. H. Weigl, "Microfluidic Devices Based on Laminar Fluid Diffusion
Interface" smallTalk 2001, San Diego,CA fall 2001.
B. H.Weigl "Microfluidics-based lab-on-a-chip systems",
IVD Technology Nov/Dec 2000, vol 6: pp.47-53, 2000.
B. H. Weigl, A. Hatch, A. Kamholz, P. Yager ,"Novel Immunoassay
Formats for Integrated Microfluidic Circuits - Diffusion Immunoassays
(DIA)", Micro- & Nanotechnology for Biomedical and Environmental
Applications, SPIE 2000, Proceedings of SPIE 3912:50-56.
B. H. Weigl, R. L. Bardell, T. H. Schulte ,C. Williams, "Passive
Microfluidics- Ultra-Low-Cost Plastic Disposable Lab-on-a-chips",
uTAS 2000 Proceedings, pp.299, 2000, D. J. Harrison and A. van den Berg,
eds. Kluwer Academic Publishers, Dordrecht, (2000)
P. Yager, K. Cabrera, A. Hatch, K. Hawkins, M. Holl, A. Kamholz, Macounova,
B. H. Weigl "Analytical Devices Based on Transverse Transport in
Microchannels", uTAS 2000, p.15, May 2000. D. J. Harrison and A.
van den Berg, eds. Kluwer Academic Publishers, Dordrecht, (2000)
A. Kamholz, B. H. Weigl, B. A. Finlayson, P. Yager, "Quantitative
Analysis of Molecular Interaction in a Microfluidici Channel: the T-Sensor",
Anal. Chem. Vol 71, part 23, Dec 15, 1999.
A. Hatch, B. H. Weigl, M. D. Zebert, P. Yager, "Microfluidic
approaches to immunoassays", SPIE Conference Santa Clara, Sep 1999.
B. H. Weigl, P. Yager, "Microfluidic Diffusion-Based Separation
and Detection", Science,15:346-347, January 1999.
B.H. Weigl, "Microfluidic diffusion-based separation and detection
technology for Lab-on-a-chip Applications" (invited lecture), SmallTalk
99, Microfluidics and Microarray Conference, San Diego, CA, June 1999.
B. H. Weigl, R. B. Darling, P. Yager, J. Kriebel, K. Mayes, "Optical
and electrochemical diffusion-based detection of analytes in complex samples
using microfabricated flow structures (T-Sensors TM)",
Micro- & Nanofabricated Structures for Biomedical and Environmental Applications
II, SPIE 1999, 3606:82-89.
B.H. Weigl, " Whole Blood Assays Using Microfluidics-Based T-Sensor
Technology", Medical Design Online, http://news.medicaldesignonline.com/feature-articles/19990416-5922.html,
04-1999.
B.H. Weigl, "Tumor Marker Diagnostics Using Microfluidics-Based
Separation and Detection Technology for Lab-on-a-Chip Applications" (invited
presentation), First NASA & NCI Workshop on Sensors for Bio-Molecular
Signatures, Pasadena. CA, June 2 – 4, 1999.
P. Yager, M.A. Afromowitz, D. Bell, F.K. Forster, J.P. Brody, D. Qin,
C. Cabrera, M. Holl, A. Kamholz, and B.H. Weigl, "Design of microfluidic
sample preconditions systems for detection of biological agents in environmental
samples" , SPIE, vol. 3515, 252-259 (1998).
P. Yager, D. Bell, J.P. Brody, D. Qin, C. Cabrera, A. Kamholz, and
B.H. Weigl, " Applying microfluidic chemical analytical systems to imperfect
samples", uTAS 98, D.J. Harrison and A. van den Berg, eds., Kluwer Academic
Publishers, Dordrecht, 207-212 (1998).
B.H. Weigl, R. Darling, J. Kriebel, K. Mayes, P. Yager, Microfluidic
diffusion based electrochemical detection using microfabricated flow structures
(T-Sensors)
B.H. Weigl, J. Kriebel, K. Mayes, P. Yager, CC Wu, M. Holl, M Kenny,
D. Zebert, " Simultaneous self-referencing analyte determination
in complex sample solutions using microfabricated flow structures (T-Sensors)",
uTAS 98, D.J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers,
Dordrecht, (1998).
R. Darling, P. Yager, B. H. Weigl, J. Kriebel, K. Mayes "Integration
of microelectrodes with etched microchannels for in-stream electrochemical
analysis" (invited paper), uTAS 98, D.J. Harrison and A. van den Berg,
eds. Kluwer Academic Publishers, Dordrecht, (1998).
E. Altendorf, M. D. Zebert, M. Holl, A. Vannelli, C. C. Wu, T. H. Schulte,
"Results Obtained Using a Prototype Microfluidics-based Hematology Analyzer",
uTAS 98, D.J. Harrison and A. van den Berg, eds. Kluwer Academic
Publishers, Dordrecht, (1998).
B.H. Weigl, J. Kriebel, K. Mayes, T. Buj, P. Yager, "Whole blood
diagnostics in standard gravity and microgravity using microfluidic structures
(T-SensorsTM)" (invited paper), Microchimica Acta, 1998.
B.H. Weigl and P. Yager, "Silicon-Microfabricated Diffusion-Based
Optical Chemical Sensor, Sensors & Actuators", B – Chemical, 38-39 (1997)
pp 452-457.
C.C. Wu, B. H. Weigl, T. Truong, M. Kenny, "Comparison of data
reduction schemes for fluorometric analysis of albumin on a si-chip",
Academy of Clinical Laboratory Physicians and Scientists, 1997.
P. Galambos, F. Forster, B. H. Weigl, " A method for determination
of pH Using a T-Sensor", Transducers 97, Category 5 -Chemical Sensors,
1997.
B.H. Weigl, G. T. Hixon, P. Yager, "Fluorescence and absorbance
analyte sensing in whole blood based on diffusion separation in silicon-microfabricated
flow structures" (invited paper), SPIE Proceedings, J. Lakowitz (ed.),
Fluorescence Sensing Technology III, 1997.
B.H. Weigl, G. T. Hixon, M. A Kenny, D. Zebert, S. Dwinnel, T. Buj,
P. Yager, "Fluorescence and absorption analyte sensing in whole
blood based on diffusion separation in silicon-microfabricated flow structures
(T-SensorsTM)" (invited paper), Biomedical Optics, Vol. 6, No.1, 1997.
B.H. Weigl, G. van den Engh, R. Kaiser, E. Altendorf, and P. Yager,
" Rapid Sequential Chemical Analysis Using Multiple Fluorescent Reporter
Beads", µTAS 96, Conference Proceedings, 1996.
E. Altendorf, E. Iverson, D. Schutte, B. H. Weigl, T. Osborn, R. Sabeti,
and P. Yager, " Optical Flow Cytometry Utilizing Microfabricated
Silicon Flow Channels", Advanced techniques in analytic Cytology (BIOS
96) SPIE Proc Vol 2678.
B.H. Weigl, M. A. Holl, D. Schutte, J. P. Brody, and P. Yager,
"Diffusion-Based Optical Chemical Detection in Silicon Flow Structures",
Analytical Methods and Instrumentation, µTAS 96 special edition, 1996.
D. Zebert, M. A Kenny, J. S. Kenny, and B. H. Weigl, "Serum
Albumin Analysis Using AB 580, a Fluorescent Dye" , AACC National Meeting,
Chicago, 1996.
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